Watch Indianapolis Colts vs. Seattle Seahawks live on NBC

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The Seattle Seahawks host the Indianapolis Colts on Sunday Night Football as both teams look to get back to .500.

Russell Wilson will be the focal point of the Seahawks offense after throwing for a career-high 373 yards and four touchdowns in a losing effort vs. the Titans in Week 3. Wilson’s ability to avoid the rush and use his legs will be on full display as Seattle’s offensive line continues to struggle.

On the defensive side, the Seahawks’ “Legion of Boom” will look to get back on track at home in a raucous environment against Colts QB Jacoby Brissett who is filling in for an injured Andrew Luck.

If the Colts have any chance to pull off the upset on the road, Brissett will have to use his legs and connect on some deep throws to T.Y. Hilton.

Football Night in America

Start time: 7:00 p.m. ET

TV channel: NBC

Live stream: NBCSports.com, NBC Sports app

Colts vs. Seahawks

Start time: 8:30 p.m. ET

TV channel: NBC

Live stream: NBCSports.com, NBC Sports app

Week 16 NFL opening odds have Giants, Raiders, Steelers as favorites

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There is reason to think Eli Manning and the New York Giants will maintain their record of being a near-lock when favored by a field goal or less.

While they’re on the road, the Giants are listed as 2.5-point favorites against the Philadelphia Eagles in the Thursday Night Football matchup at sportsbooks monitored by OddsShark.com.

New York is 6-1-1 against the spread in its last eight games as a favorite of three or fewer points, while the Eagles will be out to break a negative trend of being 0-4 straight-up and ATS in their last four divisional games.

Manning and WR Odell Beckham Jr. are facing an Eagles defense whose yards per pass allowed has ballooned to 7.7, 26th in the 32-team NFL. The Giants’ improving defense could fluster rookie QB Carson Wentz, whose complement of receivers might struggle with getting separation from the trio of Eli Apple, Janoris Jenkins and Dominique Rodgers-Cromartie.

Elsewhere, the Oakland Raiders are 3.5-point favorites against the Indianapolis Colts. Each team’s chances ride heavily on their respective quarterbacks, Andrew Luck and Derek Carr. The status of Colts RT Joe Reitz (back), who would be matched up on pass rusher extraordinaire Khalil Mack, is in doubt. The Raiders are 2-8 ATS in their last 10 home games according to the OddsShark NFL Database.

The Buffalo Bills are 3.5-point favorites against the Miami Dolphins. The Dolphins control their playoff destiny but are 2-9 ATS in their last 11 road games against Buffalo. The Bills’ run defense is a mess and RB Jay Ajayi might be able to provide the necessary support for backup QB Matt Moore, who is coming off a four-touchdown game in Week 15.

The Pittsburgh Steelers are 4.5-point favorites against the Baltimore Ravens in a Christmas Day betting matchup. While Baltimore is on a 7-0 ATS streak in AFC North games, Ravens QB Joe Flacco‘s offense is more sporadic than the unit led by Steelers QB Ben Roethlisberger. The Ravens are 0-7 SU and 1-6 ATS in their last seven games in the late afternoon.

The Kansas City Chiefs are favored by four points against the Denver Broncos in the Sunday Night Football matchup. Although the Chiefs are coming off a loss against Tennessee, they regularly disrupt quarterbacks through DE Chris Jones, OLB Dee Ford and OLB Justin Houston. Denver QB Trevor Siemian and his offensive line haven’t been able to withstand that very often this season.

And the Dallas Cowboys are favored by seven points against the Detroit Lions in the Monday Night Football matchup. Lions QB Matthew Stafford has a chance to put up some points and Detroit’s defense, which allows an average of 98.9 rushing yards, might be able to limit NFL rushing leader Ezekiel Elliott. The Cowboys are not only on an 0-4 ATS streak, but they are 3-10-1 ATS in their last 14 home games against teams with winning records.

NFL Thanksgiving odds: Cowboys, Lions both betting favorites for Thursday

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The line has shifted well in favor of Dak Prescott and the Dallas Cowboys as they renew their historic NFC East rivalry with the Washington Redskins on Thanksgiving Day. The NFC-leading Cowboys are 7.5-point favorites on the NFL point spreads against Washington, with a 51-point total, at sportsbooks monitored by OddsShark.com.

Dallas is 9-1 straight-up and 3-7 against the spread in its last 10 games as a favorite of seven points or more, while Washington is 5-0 SU and ATS in its last five games as a road underdog of 7.5 points or fewer.

Dallas is 9-1 SU and 9-0-1 ATS on the season. Prescott has proven to be a superb decision-maker and should once again get ample rushing support from Ezekiel Elliott and perhaps the NFL’s best offensive line. Washington also allows 4.6 yards per carry, second-worst in the NFL. Tight end Jason Witten also has an excellent matchup.

Washington, which is 6-3-1 SU and 7-3 ATS, will also pit a potent offense against a mid-level Dallas defense. Quarterback Kirk Cousins is benefiting from balance in the receiving corps with deep threat DeSean Jackson healthy and able to clear space for WR Pierre Garcon and WR Jamison Crowder.

The total has gone over in 13 of the Redskins’ last 15 games.

Thursday begins with an NFC North first-place showdown, as the Detroit Lions are the 2.5-point favorite against the Minnesota Vikings with a 43-point total. Matthew Stafford and the Lions, who are 6-4 SU and ATS, are the hotter team coming in but have a tough matchup against a Vikings defense that allows the second-fewest yards per pass (6.2).

The Vikings, also 6-4 SU and ATS, are trying to turn around a woeful rushing attack in order to reduce the pressure on QB Sam Bradford. Minnesota is 9-2 SU in their last 11 games as an underdog of 2.5 or fewer points. Five of the teams’ last six games have finished under.

And the likelihood of Andrew Luck (concussion protocol) being unable to play during a short week has cast the Pittsburgh Steelers as the nine-point road favorite on the moving betting line against the Indianapolis Colts. The total is 47 points.

The Steelers and Colts are each 5-5 both SU and ATS. Pittsburgh QB Ben Roethlisberger and RB Le'Veon Bell, based on form, could have a big night against a Colts defense that has the lowest interception rate in the NFL. Pittsburgh is 2-8 ATS in its last 10 November games, which seems low for a consistent playoff team.

Scott Tolzien, who hasn’t thrown a meaningful pass since 2013, is the Colts’ backup QB. The Colts have been consistently churning out yardage and the Steelers defense has yet to find a rhythm, but playing Tolzien would probably hasten using a limited playbook.

The last four Steelers-Colts games have gone over the posted total at the sportsbooks.