Injuries a factor in NFL Week 2 betting lines

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( Week 1 of the NFL season was marked by serious injuries to a number of star players that may have lasting implications for their respective teams, including the Dallas Cowboys who travel to Philadelphia on Sunday to face the division-rival Eagles as early 4-point underdogs at sportsbooks monitored by

The Cowboys eked out a last-minute 27-26 win over the New York Giants on Sunday night, failing to cover as 7-point favorites. However, the victory came at a heavy cost, as star wide receiver Dez Bryant left the game with a broken foot that could sideline him up to two months.

Philadelphia enters Sunday afternoon’s Cowboys vs. Eagles betting matchup at Lincoln Financial Field still searching for their first win after coming up short in a 26-24 Week 1 loss to Atlanta as 3.5-point road chalk on Monday night, dropping them to 1-4 straight up and against the spread in their past five games.

Elsewhere, things keep getting worse in the nation’s capital where the Washington Redskins will be without three starters, including injured wide receiver DeSean Jackson, when they host the St. Louis Rams on Sunday afternoon as 3-point underdogs at the sportsbooks.

Jackson will be lost for about a month with a hamstring injury suffered in the Redskins’ 17-10 loss to the Miami Dolphins in Week 1. The SU loss drops Washington to 1-8 SU in their last nine games, 2-7 ATS.

The Rams are coming off their second straight upset victory at home over Seattle last weekend, edging the Seahawks 34-31 to end a three-game SU and ATS losing streak.

St. Louis is 2-0 SU and ATS in its last two games against the Redskins, including a 24-0 beating in Washington last season, and is 6-1 ATS in its last seven against the Redskins, including three outright victories as betting underdogs.

The Indianapolis Colts could be without wide receiver T.Y. Hilton when they battle the New York Jets on Monday Night Football, pegged as 7-point favorites.

Indianapolis recorded a stunning 27-14 loss to the Buffalo Bills in Week 1, and has suffered outright losses as betting favorites in three of their last five home games against the Jets according to the OddsShark NFL Database.

In other NFL Week 2 betting action, the Bills are pegged as home underdogs for a second straight week, with the New England Patriots visiting as early 1-point favorites, while the Cleveland Browns host Marcus Mariota and the Tennessee Titans as 2.5-point chalk, and the Green Bay Packers take on the Seahawks as 3.5-point favorites.

Broncos double-digit favorites on Sunday night vs. winless, depleted Giants

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The Denver Broncos head into Sunday night with the largest spread they have had at home after a bye week in at least 25 years. The Broncos are 11.5-point favorites against the winless New York Giants with a 38.5-point total for the Week 6 Sunday Night Football matchup at sportsbooks monitored by

Denver is 6-1 straight-up and against the spread in post-bye week games dating back to 2010. There’s a similar long-running trend of Denver being 7-2 SU and ATS in home games following a bye week since 2003. However, this is the first time since 1996 that Denver has been a double-digit favorite in that scenario.

The Giants, which are 0-5 SU and 2-3 ATS, had three wide receivers, including Odell Beckham Jr., sustain season-ending injuries last week. That has left QB Eli Manning with WR Roger Lewis (15 career catches) and WR Tavarres King as his main outside targets. Slot WR Sterling Shephard (sprained ankle) could be inactive.

While team performances tend to gravitate toward the mean with time, the Giants will need to show something new – with replacement-level personnel – in order to move the ball against a Denver pass defense which allows only 6.2 yards per pass, fifth-best in the NFL.

The Broncos’ top-ranked defense, led by OLB Von Miller, is also first in run defense and has every starter healthy. While NFC teams are a combined 1-10 SU on the road against Denver since 2012, the Giants are a solid 7-3 ATS in their last 10 games against the AFC.

Denver, 3-1 SU and 2-1-1 ATS, has been quietly efficient on offense. The Broncos, with QB Trevor Siemian, are in the middle of the NFL pack in yards per pass, but they are facing a Giants secondary that is minus CB Dominique Rodgers-Cromartie (suspension) and has also had inconsistent play from CB Eli Apple.

Denver, 7-2 ATS over its last nine home games in October, has been good at opening holes for the tandem of C.J. Anderson and Jamaal Charles, who are each capable of making things happen in the open field if the tackling gets sloppy. New York also won’t have DT Olivier Vernon drawing double teams up front and keeping blockers off MLB Damon Harrison.

Unless the Broncos stop themselves, they should be able to grind out a workmanlike win.

The total has gone over in three of the Giants’ last four games against the Broncos, according to the OddsShark NFL Database. The total has gone over in six of the Broncos’ last seven games as a favorite of 11.0 points or more.

For more info, picks and a breakdown of this week’s top sports betting news check out the new OddsShark podcast with Jon Campbell and Andrew Avery. Subscribe on iTunes, or check it out at

Watch Indianapolis Colts vs. Seattle Seahawks live on NBC


The Seattle Seahawks host the Indianapolis Colts on Sunday Night Football as both teams look to get back to .500.

Russell Wilson will be the focal point of the Seahawks offense after throwing for a career-high 373 yards and four touchdowns in a losing effort vs. the Titans in Week 3. Wilson’s ability to avoid the rush and use his legs will be on full display as Seattle’s offensive line continues to struggle.

On the defensive side, the Seahawks’ “Legion of Boom” will look to get back on track at home in a raucous environment against Colts QB Jacoby Brissett who is filling in for an injured Andrew Luck.

If the Colts have any chance to pull off the upset on the road, Brissett will have to use his legs and connect on some deep throws to T.Y. Hilton.

Football Night in America

Start time: 7:00 p.m. ET

TV channel: NBC

Live stream:, NBC Sports app

Colts vs. Seahawks

Start time: 8:30 p.m. ET

TV channel: NBC

Live stream:, NBC Sports app